Actualizări în tratamentul hormonal al cancerului de sân

Hormonal cancer what is

It is possible that HER2 human epitelial growth factor receptor 2 to have an influence on the response or resistance to hormonal treatment. Hormonal cancer treatment side effects article presents the main classes of drugs used in hormonal treatment and their indication, improvements obtained and future perspectives of research. Updates in the hormonal treatment of breast cancer El este aplicat la pacientele la care se identifică în ţesutul tumoral prezenţa receptorilor hormonali ER - receptor estrogen şi PGR - receptor progesteron. Este posibil ca şi statusul HER2 receptorul 2 al factorului de creştere epidermal uman să aibă influenţă asupra răspunsului şi rezistenţei la tratamentul hormonal. Articolul are drept scop prezentarea principalelor clase de medicamente folosite în tratamentul hormonal şi a prinicipalelor indicaţii, progrese înregistrate şi perspective de viitor.

It is applied in patients expressing tumoral hormone receptors ER - estrogen receptor and PGR - progesteron receptor. It is possible that HER2 human epitelial hormonal cancer what is factor receptor 2 to have an influence on the response or resistance to hormonal treatment.

This article presents the main classes of drugs used in hormonal treatment and their indication, improvements obtained and future perspectives of research. El este aplicat la pacientele la care se identifică în ţesutul tumoral prezenţa receptorilor hormonali ER - receptor estrogen şi PGR - receptor progesteron.

hormonal cancer what is

Este posibil ca şi statusul HER2 receptorul 2 al factorului de creştere epidermal uman să hormonal cancer what is influenţă asupra răspunsului şi rezistenţei la tratamentul hormonal. Articolul are drept scop prezentarea principalelor clase de medicamente folosite în tratamentul hormonal şi a prinicipalelor indicaţii, progrese înregistrate şi perspective de viitor.

Actualizări în tratamentul hormonal al cancerului de sân

Cuvinte cheie tratament hormonal cancer de sân modulatori selectivi ai receptorului de estrogen inhibitori de aromatază Introduction Hormones are molecules that act like chemical messengers in the human body. Their main circulating path is through the blood stream.

CANTO study: impact of breast cancer hormone therapy on quality of life

Estrogen and progesteron are made in the ovaries in premenopausal women, and in other tissues including fat in postmenopausal women. Apart from their classic role female sex characteristics, pregnancy etc.

hormonal cancer what is

To determine the hormonal status, tissue from the tumour is needed. It can be obtained either by biopsy, or by surgery.

И в следующее мгновение не осталось ничего, кроме черной бездны.

Main hormone therapy classes Blocking ovarian function - ovaries are the main production site of estrogen in premenopausal women. Blocking of their function can be achieved by either removing ovaries surgically, or by radiation both being definitive methods or, most frequently used today, inhibiting their function temporarily by using gonadotropin releasing hormone GnRH agonists or luteinizing hormone releasing hormone LH-RH agonists.

Examples: goserelin and leuprolide.

  • Был субботний вечер, и севильский морг не работал.
  •  - Я люблю .
  • Îndepărtarea verucilor genitale în preparatele locurilor intime

The main side effects of these therapies are bone loss, mood swings, depression, and loss of libido. Blocking estrogen production - aromatase inhibitors AI are used to block the production of estrogens from fat and other tissues.

Hormonal cancer treatment side effects

They can be given alone in postmenopausal women or in association with ovarian suppression in premenopausal setting. Examples: anastrozole, letrozole - both inactivate temporarily the aromatase enzyme non-steroidal AI - or exemestane, which inactivates the enzyme permanently steroidal AI.

The main side effects are: risk of heart attack, angina, heart failure, and hypercholesterolemia, bone loss, joint pain, mood swings and depression.

hormonal cancer what is

Blocking estrogens effects - two drugs block the action of estrogen on the breast tumour cells. Selective estrogen receptor modulating agents SERMs : they bind to the receptor, blocking it, thus preventing the binding of estrogen.

  • В то время как даже при нынешнем рекорде - сто пятьдесят вскрытых шифров в день - они не успевают расшифровывать всю перехватываемую информацию.
  • Сьюзан открыла .
  • Paraziți și corpul uman

Examples: tamoxifen and toremifen. They act like antagonists in some tissues tumour cells and agonists in other uterus, boneinfluencing their safety profile.

hormonal cancer what is

Common adverse reactions: risk of blood clots, especially in the lungs and legs, stroke, cataract, endometrial cancer, bone loss in premenopausal women. Other antiestrogen drugs, like fulvestrant: they act similarly to tamoxifen, but without the agonist effect. Furthermore, after binding to the estrogen receptor, they programme it for destruction.

 Зачем же ты убил Чатрукьяна? - бросила .

This explains the better safety profile and side effects: gastrointestinal symptoms, elevated liver functional tests, loss of strength and pain Taking into account the medical history of patients and other treatments they are undergoing, we must be careful for interactions. For tamoxifen, caution must be taken for patients in treatment with antidepressants from the class of selective serotonin reuptake inhibitors SSRI like paroxetine, which inhibits enzyme CYP2D6.

hormonal cancer what is

They slow down tamoxifen metabolization and reduce its effects. Safer alternatives are available, like sertraline, venlafaxine or even considering changing tamoxifen with AI. Treatment protocols Prevention. The same indication for AI is still under investigation 8. There have been several studies investigating this option, mainly using AI.

hormonal cancer what is